Pharmacogenetics
BioCertica Pharmacogenetics is the study of how a person’s genes affect their response to drugs, with the goal of tailoring medication selection and dosage to individuals for improved safety and effectiveness of the drug. Pharmacogenomic testing analyses a sample of blood or saliva for genetic variations that influence drug metabolism & response.
Pharmacogenetics For Warfarin Dose Selection
Warfarin is one of the most widely prescribed blood thinners, used to prevent strokes, heart attacks, and life threatening blood clots. But dosing is tricky—too much can lead to severe bleeding, while too little increases the risk of clot formation,
Warfarin pharmacogenetic testing examines specific genes that influence how your body processes this medication. By understanding your genetic profile, doctors can determine the safest and most effective dose tailored to you.
Key Genes Analyzed
- CYP2C9 – Determines how quickly Warfarin is metabolized.
- VKORC1 – Influences your sensitivity to Warfarin.
- CYP4F2 – Regulates vitamin K metabolism, indirectly impacting Warfarin activity.
Benefits of Genetic Testing
- Precise, individualized dosing for better outcomes
- Reduced risk of bleeding or clotting complications
- Safer, faster treatment with fewer trial‑and‑error adjustments
Pharmacogenomics for Selection of Statin & It’s Dose
Statins are essential for lowering cholesterol and protecting against cardiovascular disease. However, not everyone responds the same way to Statin. Pharmacogenomic testing for statins helps identify genetic variations that affect drug metabolism, reducing the risk of muscle pain, liver issues, and other side effects.
Personalized Statin Response Testing
Statins are among the most trusted treatments for managing cholesterol and protecting cardiovascular health. Yet, some people experience muscle pain, weakness, or intolerance because their body processes statins differently.
With our Statin Response Pharmacogenetic Test, your clinician gain clarity on how your genes influence your reaction to statin medications—helping him choose the safest and most effective dose of Statin for you.
Key Gene Analyzed: SLCO1B1*5
Variants in the SLCO1B1 gene can slow statin transport in the liver. This increases the likelihood of muscle-related side effects and treatment intolerance.
Identifying this gene variation empowers your doctor to prescribe the right statin, at the right dose, from the very beginning.
Why Clopidogrel Matters
Clopidogrel is a widely prescribed anti‑platelet medication used to prevent blood clots after stent placement or heart attacks. For many patients, it’s life‑saving. But here’s the challenge: not everyone’s body can convert Clopidogrel into its active form. When this happens, the drug becomes ineffective, leaving patients at risk of dangerous cardiac events.
Genetic Insights: Key Gene Tested
Our Clopidogrel pharmacogenetic testing analyzes variations in the CYP2C19 gene, which directly impacts how your body metabolizes the drug:
- CYP2C192* – Poor metabolism → reduced drug effectiveness, higher risk of clotting events.
- CYP2C193* – Associated with increased cardiovascular risk.
- CYP2C1917* – Increased enzyme activity → may alter drug response.
Benefits of Clopidogrel Genetic Testing
- Avoid treatment failure by knowing if Clopidogrel will work for you.
- Consider alternative anti‑platelet therapies if genetic variants reduce effectiveness.
- Lower risk of recurrent heart attacks or stent thrombosis with personalized treatment decisions.